Igraph:使用graph时顶点名称无效。edgelist和not graph\u from\u data\u frame

根据我使用下面一行代码的情况,我会得到一个错误。
这个很好用。

   g <- igraph::graph_from_data_frame(d.int, directed = TRUE)

使用此方法创建igraph对象时出错。

   g <- igraph::graph.edgelist(as.matrix(unique(d.int[, c(1, 3)])), directed = FALSE)

错误为:

"Invalid vertex names"

为什么?

第二行使用的d.int数据帧(sif格式)是:

           a.gn    b.gn                     type
24115     KLRD1    CD3G controls-state-change-of
24132     KLRD1  FCGR1A controls-state-change-of
24150     KLRD1  TYROBP          in-complex-with
28674     ITGA4   VCAM1          in-complex-with
28676     ITGA4   ITGB7          in-complex-with
28677     ITGA4   ITGAL   controls-expression-of
28678     ITGA4   ITGB1          in-complex-with
30999    TYROBP    CD3G controls-state-change-of
31018    TYROBP  FCGR1A controls-state-change-of
44607     ITGAL   ITGB2          in-complex-with
44608     ITGAL   ITGA4   controls-expression-of
69420   CD300LB  TYROBP          in-complex-with
75890       B2M  TYROBP          in-complex-with
75905       B2M    CD8A          in-complex-with
75911       B2M    CD3D          in-complex-with
75915       B2M  FCGR1A controls-state-change-of
75916       B2M KIR3DL1          in-complex-with
75919       B2M  LILRB2          in-complex-with
75941       B2M    CD3G          in-complex-with
75942       B2M    CD3G controls-state-change-of
75944       B2M   HLA-G          in-complex-with
75952       B2M   HLA-F          in-complex-with
75956       B2M  LILRB1          in-complex-with
75970       B2M   HLA-C          in-complex-with
76007       B2M  LILRA4          in-complex-with
76063       B2M   HLA-A          in-complex-with
76067       B2M KIR3DL2          in-complex-with
76086       B2M   KLRC1          in-complex-with
76087       B2M   HLA-B          in-complex-with
76100       B2M KIR2DL3          in-complex-with
76114       B2M   HLA-E          in-complex-with
76128       B2M    CD1D          in-complex-with
76129       B2M   KLRD1          in-complex-with
76130       B2M KIR2DL1          in-complex-with
76616    COL1A1  COL1A2          in-complex-with
78596      CD19    CD81          in-complex-with
78620      CD19  IFITM1          in-complex-with
78706      CD19    CD3G controls-state-change-of
78717      CD19  FCGR1A controls-state-change-of
88285     ICAM2   ITGAL          in-complex-with
88286     ICAM2   ITGB2          in-complex-with
94075     ICAM3   ITGB2          in-complex-with
94076     ICAM3   ITGAL          in-complex-with
101887     CD3D    CD8A          in-complex-with
101895     CD3D   HLA-A          in-complex-with
101915     CD3D    CD3G          in-complex-with
101916     CD3D   HLA-G          in-complex-with
101919     CD3D   HLA-B          in-complex-with
101926     CD3D   HLA-F          in-complex-with
101938     CD3D   HLA-C          in-complex-with
101961     CD3D   HLA-E          in-complex-with
109005    HLA-G  LILRB2          in-complex-with
109024    HLA-G  LILRA4          in-complex-with
109028    HLA-G  LILRB1          in-complex-with
121205     CD3G   HLA-A          in-complex-with
121225     CD3G   HLA-B          in-complex-with
121281     CD3G  FCGR1A          in-complex-with
121297     CD3G   HLA-G          in-complex-with
121306     CD3G   HLA-F          in-complex-with
121317     CD3G   HLA-C          in-complex-with
121419     CD3G   HLA-E          in-complex-with
121456     CD3G    CD8A          in-complex-with
137496     CDH1   KLRG1          in-complex-with
137498     CDH1   ITGB7          in-complex-with
150270    HLA-A  LILRB1          in-complex-with
150280    HLA-A  LILRA4          in-complex-with
150287    HLA-A KIR3DL2          in-complex-with
150296    HLA-A  LILRB2          in-complex-with
155691    CD200 CD200R1          in-complex-with
156706    ICAM1   ITGAL          in-complex-with
156707    ICAM1   ITGB2          in-complex-with
157374    KLRC1   KLRD1          in-complex-with
168591    ITGB1   VCAM1          in-complex-with
179866     CD96     PVR          in-complex-with
179910    KLRK1  TYROBP          in-complex-with
179915    KLRK1  RAET1E          in-complex-with
179921    KLRK1    CD3G controls-state-change-of
179937    KLRK1  FCGR1A controls-state-change-of
179980    KLRK1    MICB          in-complex-with
180078    KLRK1    MICA          in-complex-with
183355     CD1D    CD3G          in-complex-with
183360     CD1D    CD3D          in-complex-with
201658    ICAM4   ITGB2          in-complex-with
201659    ICAM4   ITGAL          in-complex-with
227035    HLA-C  LILRB2          in-complex-with
227037    HLA-C KIR2DL1          in-complex-with
227039    HLA-C  LILRA4          in-complex-with
227055    HLA-C  TYROBP          in-complex-with
227056    HLA-C  LILRB1          in-complex-with
227064    HLA-C KIR2DL3          in-complex-with
230227    HLA-B  LILRA4          in-complex-with
230243    HLA-B KIR3DL1          in-complex-with
230245    HLA-B  LILRB2          in-complex-with
230257    HLA-B  LILRB1          in-complex-with
230258    HLA-B  TYROBP          in-complex-with
235388   CLEC2D   KLRB1          in-complex-with
237811       C3  IFITM1          in-complex-with
237814       C3    CD19          in-complex-with
237820       C3    CD81          in-complex-with
237945    CD226     PVR          in-complex-with
257417     CD81  IFITM1          in-complex-with
264111    ICAM5   ITGAL          in-complex-with
264112    ICAM5   ITGB2          in-complex-with
285674    HLA-F  LILRB2          in-complex-with
285682    HLA-F  LILRA4          in-complex-with
285695    HLA-F  LILRB1          in-complex-with
307587     CD99   PILRA          in-complex-with
309539    HLA-E   KLRD1          in-complex-with
309589    HLA-E   KLRC1          in-complex-with
309610    HLA-E    CD3G controls-state-change-of
309628    HLA-E  FCGR1A controls-state-change-of
309629    HLA-E  LILRB2          in-complex-with
309645    HLA-E  TYROBP          in-complex-with
309653    HLA-E  LILRA4          in-complex-with
309698    HLA-E  LILRB1          in-complex-with
341342    TREM1  TYROBP          in-complex-with
342749     CD8A   HLA-B          in-complex-with
342752     CD8A   HLA-A          in-complex-with
342755     CD8A   HLA-C          in-complex-with
342756     CD8A   HLA-F          in-complex-with
342760     CD8A   HLA-G          in-complex-with
342761     CD8A   HLA-E          in-complex-with
360361   FCGR1A    NCR3          in-complex-with
241501   TYROBP   KLRD1          in-complex-with
286741    VCAM1   ITGA4          in-complex-with
286761    ITGB7   ITGA4          in-complex-with
286781    ITGB1   ITGA4          in-complex-with
446071    ITGB2   ITGAL          in-complex-with
694201   TYROBP CD300LB          in-complex-with
758901   TYROBP     B2M          in-complex-with
759051     CD8A     B2M          in-complex-with
759111     CD3D     B2M          in-complex-with
759161  KIR3DL1     B2M          in-complex-with
759191   LILRB2     B2M          in-complex-with
759411     CD3G     B2M          in-complex-with
759441    HLA-G     B2M          in-complex-with
759521    HLA-F     B2M          in-complex-with
759561   LILRB1     B2M          in-complex-with
759701    HLA-C     B2M          in-complex-with
760071   LILRA4     B2M          in-complex-with
760631    HLA-A     B2M          in-complex-with
760671  KIR3DL2     B2M          in-complex-with
760861    KLRC1     B2M          in-complex-with
760871    HLA-B     B2M          in-complex-with
761001  KIR2DL3     B2M          in-complex-with
761141    HLA-E     B2M          in-complex-with
761281     CD1D     B2M          in-complex-with
761291    KLRD1     B2M          in-complex-with
761301  KIR2DL1     B2M          in-complex-with
766161   COL1A2  COL1A1          in-complex-with
785961     CD81    CD19          in-complex-with
786201   IFITM1    CD19          in-complex-with
882851    ITGAL   ICAM2          in-complex-with
882861    ITGB2   ICAM2          in-complex-with
940751    ITGB2   ICAM3          in-complex-with
940761    ITGAL   ICAM3          in-complex-with
1018871    CD8A    CD3D          in-complex-with
1018951   HLA-A    CD3D          in-complex-with
1019151    CD3G    CD3D          in-complex-with
1019161   HLA-G    CD3D          in-complex-with
1019191   HLA-B    CD3D          in-complex-with
1019261   HLA-F    CD3D          in-complex-with
1019381   HLA-C    CD3D          in-complex-with
1019611   HLA-E    CD3D          in-complex-with
1090051  LILRB2   HLA-G          in-complex-with
1090241  LILRA4   HLA-G          in-complex-with
1090281  LILRB1   HLA-G          in-complex-with
1212051   HLA-A    CD3G          in-complex-with
1212251   HLA-B    CD3G          in-complex-with
1212811  FCGR1A    CD3G          in-complex-with
1212971   HLA-G    CD3G          in-complex-with
1213061   HLA-F    CD3G          in-complex-with
1213171   HLA-C    CD3G          in-complex-with
1214191   HLA-E    CD3G          in-complex-with
1214561    CD8A    CD3G          in-complex-with
1374961   KLRG1    CDH1          in-complex-with
1374981   ITGB7    CDH1          in-complex-with
1502701  LILRB1   HLA-A          in-complex-with
1502801  LILRA4   HLA-A          in-complex-with
1502871 KIR3DL2   HLA-A          in-complex-with
1502961  LILRB2   HLA-A          in-complex-with
1556911 CD200R1   CD200          in-complex-with
1567061   ITGAL   ICAM1          in-complex-with
1567071   ITGB2   ICAM1          in-complex-with
1573741   KLRD1   KLRC1          in-complex-with
1685911   VCAM1   ITGB1          in-complex-with
1798661     PVR    CD96          in-complex-with
1799101  TYROBP   KLRK1          in-complex-with
1799151  RAET1E   KLRK1          in-complex-with
1799801    MICB   KLRK1          in-complex-with
1800781    MICA   KLRK1          in-complex-with
1833551    CD3G    CD1D          in-complex-with
1833601    CD3D    CD1D          in-complex-with
2016581   ITGB2   ICAM4          in-complex-with
2016591   ITGAL   ICAM4          in-complex-with
2270351  LILRB2   HLA-C          in-complex-with
2270371 KIR2DL1   HLA-C          in-complex-with
2270391  LILRA4   HLA-C          in-complex-with
2270551  TYROBP   HLA-C          in-complex-with
2270561  LILRB1   HLA-C          in-complex-with
2270641 KIR2DL3   HLA-C          in-complex-with
2302271  LILRA4   HLA-B          in-complex-with
2302431 KIR3DL1   HLA-B          in-complex-with
2302451  LILRB2   HLA-B          in-complex-with
2302571  LILRB1   HLA-B          in-complex-with
2302581  TYROBP   HLA-B          in-complex-with
2353881   KLRB1  CLEC2D          in-complex-with
2378111  IFITM1      C3          in-complex-with
2378141    CD19      C3          in-complex-with
2378201    CD81      C3          in-complex-with
2379451     PVR   CD226          in-complex-with
2574171  IFITM1    CD81          in-complex-with
2641111   ITGAL   ICAM5          in-complex-with
2641121   ITGB2   ICAM5          in-complex-with
2856741  LILRB2   HLA-F          in-complex-with
2856821  LILRA4   HLA-F          in-complex-with
2856951  LILRB1   HLA-F          in-complex-with
3075871   PILRA    CD99          in-complex-with
3095391   KLRD1   HLA-E          in-complex-with
3095891   KLRC1   HLA-E          in-complex-with
3096291  LILRB2   HLA-E          in-complex-with
3096451  TYROBP   HLA-E          in-complex-with
3096531  LILRA4   HLA-E          in-complex-with
3096981  LILRB1   HLA-E          in-complex-with
3413421  TYROBP   TREM1          in-complex-with
3427491   HLA-B    CD8A          in-complex-with
3427521   HLA-A    CD8A          in-complex-with
3427551   HLA-C    CD8A          in-complex-with
3427561   HLA-F    CD8A          in-complex-with
3427601   HLA-G    CD8A          in-complex-with
3427611   HLA-E    CD8A          in-complex-with
3603611    NCR3  FCGR1A          in-complex-with