您可以使用画布:
或者使用网格并根据需要设置每个按钮的边距
<Canvas >
<Button Content="s" Width="50" Canvas.Left="17" Canvas.Top="20" />
<Button Canvas.Left="73" Canvas.Top="32" Content="s" Width="60" Height="42" />
<Button Canvas.Left="139" Canvas.Top="10" Content="s" Height="42" Width="60" />
</Canvas>
<Grid >
<Button Content="01" Height="30" Width="70" Margin="20,12,414,268" />
<Button Content="02" Height="35" Width="72" Margin="426,148,6,128" />
<Button Content="03" Height="20" Width="74" Margin="190,122,240,170" />
<Button Content="04" Height="25" Width="76" Margin="386,26,40,260" />
<Button Content="05" Height="18" Width="78" Margin="376,202,48,92" />
<Button Content="06" Height="50" Width="70" Margin="385,64,48,196" />
<Button Content="07" Height="40" Width="72" Margin="162,202,269,68" />
<Button Content="08" Height="55" Width="74" Margin="20,154,408,102" />
<Button Content="09" Height="45" Width="76" Margin="21,95,406,171" />
<Button Content="10" Height="25" Width="78" Margin="44,47,382,239" />
<Button Content="11" Height="20" Width="80" Margin="386,120,38,170" />
<Button Content="12" Height="30" Width="70" Margin="95,13,338,268" />
<Button Content="13" Height="45" Width="72" Margin="290,6,140,260" />
<Button Content="14" Height="30" Width="74" Margin="210,38,220,244" />
<Button Content="15" Height="20" Width="76" Margin="128,48,299,242" />
<Button Content="16" Height="25" Width="78" Margin="265,189,160,97" />
<Button Content="17" Height="35" Width="80" Margin="176,154,246,122" />
<Button Content="18" Height="50" Width="70" Margin="100,146,333,116" />
<Button Content="19" Height="55" Width="72" Margin="270,121,160,135" />
<Button Content="20" Height="45" Width="74" Margin="348,148,81,118" />
<Button Content="21" Height="20" Width="76" Margin="94,78,332,212" />
<Button Content="22" Height="60" Width="78" Margin="270,60,155,192" />
<Button Content="23" Height="20" Width="80" Margin="176,74,247,216" />
<Button Content="24" Height="25" Width="70" Margin="194,95,238,191" />
<Button Content="25" Height="30" Width="72" Margin="117,104,314,177" />
</Grid>